http://dynamic-brains.com/projects daily 1.0 2024-10-04 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524423098037-U3O57MY42CHZV1X039QU/SCN1A+channel+structure Projects - A deep dive into an SCN1A mutation [paper] Characterising the effects of individual mutations can yields insights about how an SCN1A mutations can lead to epilepsy. Peters et al. 2016 Sci Rep 10.1038/srep31879 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1634124505385-ODNGOU0DQEOIHQRY2OR0/fcab235ga1.jpeg Projects - Persistent sodium currents in an SCN1A degenerative encephalopathy [paper] In this work we characterise a novel gain of function variant in SCN1A associated with a severe neurodegenerative phenotype. Gorman, Peters et al. 2021 Brain Comms doi.org/10.1093/braincomms/fcab235 Twitter Thread https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1456220834970-NN2CZZ1ZQCXCN7LH6Z6K/image-asset.gif Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524423867975-84N7ZXP4TMCEUPRL3Y4U/Screen+Shot+2018-04-22+at+20.04.00.png Projects - Simulating the effects of channel abnormalities on neuron dynamics [code] This code implements the patch-clamp recordings made above in a Hodgkin-Huxley model to simulate its effects on neuronal function. Github: SCN1A Hodgkin Huxley Model https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524479812513-HWWDKGL1U7UHEISTOOO3/Capture.PNG Projects - Network dynamics in epileptic encephalopathies [paper] In this paper we illustrate how summary measures of network dynamics can separate subgroups of epilepsies in early infancy. Rosch et al (2017) Net Neurosci: 10.1162/netn_a_00026 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1617456214855-69QT785Z87IUVQTCXJZV/Screenshot+2021-04-03+at+15.12.48.png Projects - Multimodal in vivo recording using transparent graphene microelectrodes [paper] Here we present a technique to map the onset and spatiotemporal spread of acute epileptic seizures in vivo by simultaneously recording high bandwidth microelectrocorticography and calcium fluorescence using transparent graphene microelectrode arrays. Driscoll et al. (2021) Comms Biol: 10.1038/s42003-021-01670-9 Twitter Thread https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1554260805910-6PEKV2VJ3TTLQE6E57G8/Screenshot+2019-04-02+at+23.04.44.png Projects - Oscillatory brain markers of network function in adults with Down Syndrome [paper] In this paper we use EEG and Dynamic Causal Modelling to link brain oscillations, cognitive ability, and synaptic function in people living with Down Syndrome. Hamburg et al (2019) Cerebr Cort: 10.1093/cercor/bhz043 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524480069174-E9C11K3S1ASS28XEL8MG/24efc7da-25b8-11e7-8de2-9ba94c4a0818.png Projects - Quantifying network dynamics in EEG [code] This code applies dynamic network analysis on clinical EEG recordings, using a dynamic delay-delay matrix approach. Github: Dynamics Matrices https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/29af57aa-0f74-4fc4-a33e-fa0203636519/Screenshot+2024-10-04+at+12.48.10.png Projects - Ultra-long term dynamics of epileptic brain activity [preprint] Using a dynamical systems lense to understand the rhythms of epileptic brain activity over ultra-long term recordings. Rosch et al. (2024) bioRxiv: https://doi.org/10.1101/2024.07.26.605279 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1455728791535-O2P3K6V26GJSDZ8T4IJA/image-asset.gif Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1594478226170-X74A4KMUFNU5ZGY0XTB5/Screenshot+2020-07-11+at+15.36.51.png Projects - Tracking seizure dynamics with multimodal recordings [preprint] Through the use of novel transparent electrodes, we can record seizure dynamics with both electrophysiology and calcium imaging - here we present the method and an analysis pipeline. Driscoll et al (2020) bioRxiv: 10.1101/2020.06.04.134189 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524424560190-DER9A2UFEOP73WWWXWCG/Subnetworks.png Projects - Simulating epilepsy surgery in a single patient [poster] Using a dynamic causal modelling approach may be helpful to make quantitative predictions for epilepsy surgery Figshare: Patient-specific SEEG model https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/2a0c4088-7455-469a-901e-474fd7010d48/Screenshot+2024-02-13+at+12.48.47.png Projects - Local receptor fingerprints shape regional intracranial EEG signal [preprint] Brain activity varies across different cortical region - using dynamic causal modelling, we show that this is in part driven by the local distribution of neurotransmitter receptors. Stoof et al. (2023) bioRxiv: doi.org/10.1101/2024.01.09.574882 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1634124249631-NL37AG5GODUEAWY0GRN6/Screenshot+2021-10-13+at+12.23.58.png Projects - Increased modal controllability in drug resistant focal epilepsy in children [preprint] Here we investigate structural brain networks in paediatric focal epilepsies utilising a network control framework Chari et al. (2021) medRxiv: doi.org/10.1101/2021.08.05.21261484 Twitter Thread https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1562106297347-PABERNNHEYB0FH2OVCVI/Screenshot+2019-07-02+at+18.24.05.png Projects - Local spread of interictal discharges in tuberous sclerosis [preprint] Here we use dynamic causal modelling to investigate the networks that underpin the local spread of interictal discharges bioRxiv: Preprint https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524425346759-PBAEGTAFSIEDTWOIIC7S/29378229-32a5129e-82b6-11e7-90e9-3d9b14250b56.png Projects - Inferring networks from stereotactic EEG data [code] Using a mixture of functional-connectivity based approaches, and dynamic causal modelling, this code infers the generative structure underlying SEEG recordings Github: SEEG Networks https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1502491181953-6DOHJ72ETXKI0Y2JTF40/image-asset.png Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1562106457902-VAT9CG358K8FQ9YJSITB/Screenshot+2019-07-02+at+18.26.51.png Projects - Analysing travelling waves of interictal discharges from intracranial datasets This code was used to perform analysis and modelling of the spread of interictal epileptiform discharges Github: Travelling Spikes https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524426581962-M5ONKT7Y06VWQ25P818V/Screen+Shot+2018-04-22+at+20.49.09.png Projects - NMDA-receptor antibodies in mice and men [preprint] Using computational models allows us to translate between different types of observations: Here we link patient EEG recordings with observations made in an experimental mouse model. Rosch et al (2017) bioRxiv: 10.1101/160309 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524426448424-DM4FG8NSWX2UPM5IBZTT/Screen+Shot+2018-04-22+at+20.47.03.png Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/3a65d68d-6422-4098-9716-c2b71684d72e/Screenshot+2023-09-26+at+12.13.10.png Projects - Synaptic inhibition shapes benzodiazepine responses in status epilepticus [preprint] Using dynamic causal modelling we track synaptic parameters during administration of emergency medication in paediatric status epilepticus. Fedele et al. (2023) medRxiv: https://doi.org/10.1101/2023.08.23.23294456 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1634125025474-6I3VG6W7E7Q4ZP2XB771/Screenshot+2021-10-13+at+12.36.33.png Projects - Reduced excitatory neurotransmission causing seizures in NMDAR-Ab encephalitis [paper] Here we show through detailed in vitro, in vivo and in silico work that counterintuitively reduced excitation underlies seizures in a rat model of NMDAR-Ab encephalitis. Wright et al (2021) Comms Biol: doi.org/10.1038/s42003-021-02635-8 Twitter Thread https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1550069475745-YCPGHZPU9ADTC5K3H1GB/Screenshot+2019-02-13+at+14.50.39.png Projects - NMDA-receptor antibodies alter microcircuit dynamics [PNAS] The full paper from the preprint below is now out - applying computational models across mice and men to infer cortical circuitry in the presence of these pathological antibodies. Rosch et al (2018) PNAS: 10.1073/pnas.1804846115 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524427184555-MQMSCJAWQ6PQU66MBLYU/Screen+Shot+2018-04-22+at+20.57.13.png Projects - Linking EEG abnormalities and model parameters [chapter] Here we discuss the different ways computational models can be used to explain EEG abnormalities and illustrate one approach using NMDAR-Ab encephalitis as an example. Rosch et al (2016) 10.1007/978-3-319-49959-8_6 [link to author manuscript] https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1617443066286-A18OC4OE9HI4XZ0YR6PN/Screenshot+2021-04-03+at+11.38.11.png Projects - Imaging epilepsy in larval zebrafish [review] In this review we summarise the state of Calcium imaging in larval zebrafish models of epilepsy and its theoretical foundations. Burrows et al. (2020) Eur J Paed Neurol: 10.1016/j.ejpn.2020.01.006 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524430210620-XGFF4HT74OTM1EVACW8S/Fig+2+Sensorspace.png Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524432754120-REXYNGI5KVDJ0X9UNN4A/Screen+Shot+2018-04-22+at+22.32.03.png Projects - Seizures unfolding in the zebrafish brain [preprint] This paper illustrates how computational modelling can be applied can be used to explain the brain-wide changes that occur during epileptic seizures. Rosch et al. (2017) bioRxiv: 10.1101/160259 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/58eca938-6ee2-4834-8d60-77fc7e297096/Screenshot+2023-09-26+at+12.32.04.png Projects - Spontaneous brain activity emerges from pairwise interactions in the larval zebrafish brain [preprint] Brain activity emerges from neuron-to-neuron interactions. Here we use maximum entropy modelling to explain whole-brain patterns of brain activity in larval zebrafish. Rosch et al. (2023) arXiv: https://doi.org/10.48550/arXiv.2309.05939 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/a1960e65-4c40-4709-8a35-3fde10d1d064/Screenshot+2023-04-16+at+13.43.46.png Projects - Microscale neuronal activity collectively drives chaotic and inflexible dynamics at the macroscale in seiuzres [paper] This publication interrogates the effects of microscale changes in neuronal dynamics on macroscale emergent dynamics in epileptic seizures. Burrows et al. J Neurosci (2023): doi.org/10.1523/JNEUROSCI.0171-22.2023 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1550069732574-FFOF7X4HK1XE7J3AZDOT/image.pcbi.v14.i08.g001.PNG Projects - DCM of calcium imaging in zebrafish seizures [PLoS CB] The paper below is now out in its full version, and was on the ‘virtual cover’ of PLoS Computational Biology Rosch et al (2018) PLoS Comp Biol: 10.1371/journal.pcbi.1006375 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/c6a0d539-5058-4989-94fb-c20ed9f47feb/key_image.png Projects - Maximum entropy modelling in the larval zebrafish brain [paper] We use calcium imaging data in zebrafish larvae, giving us access to the activity of single neurons across the whole brain. In this dataset, fitting a pairwise maximum entropy model allows us to reproduce activity patterns and transitions between them. Rosch et al. (2024) Phys Rev X https://doi.org/10.1103/PhysRevX.14.031050 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1594478825475-DRZ4WI9532XLINIFHF1Z/screenshot+2020-07-01+at+16.59.30.png Projects - Glia-neuron interactions in epileptic seizures [commentary] Here we discuss the implications of a very interesting zebrafish paper form researchers in Norway, investigating glial-cell contributions to seizure dynamics Rosch & Dulla (2020) Epilepsy Curr: 10.1177/1535759720906115 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1634476178993-YD44L5KEJSO743CFX8BU/Screenshot+2021-10-17+at+14.09.10.png Projects - The emergence of supercritical dynamics in epileptic seizures [preprint] In this manuscript we identify key changes in neuronal dynamics that unfold at single-cell scale in the seizing larval zebrafish brain Burrows et al. bioRxiv (2021): doi.org/10.1101/2021.10.14.464473 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524433030221-K0B1HD0ZMRYEJGT95OG1/Screen+Shot+2018-04-22+at+22.35.30.png Projects - Fitting neuronal population models to zebrafish recordings [code] This code applies dynamic causal modelling to brain-wide calcium imaging in the larval zebrafish brain Github: Zebrafish seizure modelling https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1594478540128-8SU657PS8DD4FRRD89E4/Screenshot+2020-07-11+at+15.42.04.png Projects - A Novel zebrafish model of GABRG2-associated epilepsy [paper] Lead by a team of collaborators at the University of Montreal, here we describe a new model of a human genetic epilepsy in zebrafish. Liao et al (2019) Dis Model Mechan: 10.1242/dmm.040782 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1502358191785-UNYKXME8RX3MDVMA7PY4/Screen+Shot+2017-08-10+at+10.41.59.png Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524392749473-P24X4JQGGIYCZTNM1N86/3Artboard+1.png Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524420975787-Z3HA2QAKRXXBRNEWKQUF/2015-06-24+17.36.17.jpg Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1584631312382-0QR94YW2GNT9JYBW7ULJ/ezgif-3-864d7bb07078.gif Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1455798022348-VQXTAVXOTJ9RQEUTYHTC/G_3.gif Projects http://dynamic-brains.com/about daily 0.75 2025-03-28 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524434309676-HGRE48E59ZIS1FED7D27/IMG_2864.jpg About - Dynamic Brains Insights into childhood epilepsies as dynamic disorders of the brain https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/5855f9f1-b5ab-46fa-bb40-c31b110b5f6d/image.jpg About - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1627896172160-J7D7936FFLR7I815Y60V/me_2021_formal.jpg About - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/7179a89f-2e0e-49b0-83ae-bc821398c59e/profile_books.jpg About - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1603900461050-V9GOQ86IUYDYCVKVZYPM/image.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1738332789964-UVWIY01HMK0HEW7TCR37/Screenshot+2025-01-31+at+14.13.03.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1681648344524-ZKGYM0J15UEHG6VA2WTL/Screenshot+2023-04-16+at+13.32.04.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1621783485645-T5NA8CLCHG52TI6QQLA7/Logo_AMG-Stifung_CMYK-1.jpg About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1606406027410-IA5HXSZURJNHNNDQMPXA/Screenshot+2020-11-26+at+11.53.19.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1601473539558-GI3905RDO5PH8LU4X64A/human_brain_project.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1595239618393-P2J6MYXSHHGM1KBEEYML/lockup_cloud_main.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1595191705253-Y4FSFFBW0NST1VF8AYKB/wellcome-logo-black.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1595192142189-XAAL0A0OFWY1TOBNCA91/Screenshot+2020-07-19+at+21.55.15.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1595191790513-NFSH83ZQHWX51FH6XVWY/dravet-canada-logo-main.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1525186932447-AXWQLJJQWZJ8FAUSD7F2/2016-02-07+09.02.27.jpg About http://dynamic-brains.com/richard daily 0.75 2025-03-28 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524484041755-EU4HHL1CBS48SO2SC341/DOil5jeWsAIA4p9.jpg Richard Rosch - Richard Rosch Curriculum Vitae https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524482730711-X3ZFTLVRGEWN44XALI6K/2016-02-07+08.56.33.jpg Richard Rosch - Richard Rosch Interests and Bio https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1525187012408-Y3Q08P4NZIJ30ZGKU7HR/2016-01-15+13.21.27.jpg Richard Rosch http://dynamic-brains.com/contact daily 0.75 2024-10-31 http://dynamic-brains.com/calendar daily 0.75 2024-04-18 http://dynamic-brains.com/zoom daily 0.75 2024-04-18 http://dynamic-brains.com/lab daily 0.75 2025-12-29