http://dynamic-brains.com/projects daily 1.0 2026-06-19 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524392749473-P24X4JQGGIYCZTNM1N86/3Artboard+1.png Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/f0bcb99b-8133-4c8f-bfae-25ce8e3fb767/anim.gif Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/31ff8923-95c1-4e57-8616-fde52febe8db/zf.gif Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1455798022348-VQXTAVXOTJ9RQEUTYHTC/G_3.gif Projects https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/11e60531-95c4-4f17-8f9d-4a298364b184/Screenshot+2026-06-19+at+12.25.34.png Projects - Modelling anti-LGI1 related seizures, behavioral changes and brain MRI abnormalities in rodent models [paper] Anti-LG1 autoimmune encephalitis causes seizures and cognitive deficits in humans and has now been effectively modelled in a rodent model. Upadhya et al. 2025 Brain Behav Immun 10.1016/j.bbi.2025.02.019 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1634124505385-ODNGOU0DQEOIHQRY2OR0/fcab235ga1.jpeg Projects - Persistent sodium currents in an SCN1A degenerative encephalopathy [paper] In this work we characterise a novel gain of function variant in SCN1A associated with a severe neurodegenerative phenotype. Gorman, Peters et al. 2021 Brain Comms doi.org/10.1093/braincomms/fcab235 Twitter Thread https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1634125025474-6I3VG6W7E7Q4ZP2XB771/Screenshot+2021-10-13+at+12.36.33.png Projects - Reduced excitatory neurotransmission causing seizures in NMDAR-Ab encephalitis [paper] Here we show through detailed in vitro, in vivo and in silico work that counterintuitively reduced excitation underlies seizures in a rat model of NMDAR-Ab encephalitis. Wright et al 2021 Comms Biol: doi.org/10.1038/s42003-021-02635-8 Twitter Thread https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/50ff209b-a836-4106-a2e6-e7f716686c06/Screenshot+2026-06-19+at+12.32.07.png Projects - Functional genomics in simple animal models [review] Our review on how to assess functional consequences of genomic alterations at scale in simple animal models. Rosch et al. Front Cell Neuroscie 2019 doi.org/10.3389/fncel.2019.00556 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524426581962-M5ONKT7Y06VWQ25P818V/Screen+Shot+2018-04-22+at+20.49.09.png Projects - NMDA-receptor antibodies alter microcircuit dynamics [paper] Here we apply computational models across mice and men to infer cortical circuitry in the presence of pathological NMDAR antibodies. Rosch et al (2018) PNAS: 10.1073/pnas.1804846115 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524423098037-U3O57MY42CHZV1X039QU/SCN1A+channel+structure Projects - A deep dive into an SCN1A mutation [paper] Characterising the effects of individual mutations can yield insights about how an SCN1A mutations can lead to epilepsy. Peters et al. 2016 Sci Rep 10.1038/srep31879 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524423867975-84N7ZXP4TMCEUPRL3Y4U/Screen+Shot+2018-04-22+at+20.04.00.png Projects - Simulating the effects of channel abnormalities on neuron dynamics [code] This code implements the patch-clamp recordings made above in a Hodgkin-Huxley model to simulate its effects on neuronal function. Github: SCN1A Hodgkin Huxley Model https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/08ec5517-c9f3-41ac-95c2-6b01d79e8ad3/NG2015001099TT1.jpg Projects - Rare copy number variants in absence epilepsy [paper] This is an analysis of high density SNP arrays to evaluate the contribution of rare copy number variants to common generalised epilepsy phenotypes. Addis et al 2016 Neurol Genet doi.org/10.1212/NXG.0000000000000056 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1554260805910-6PEKV2VJ3TTLQE6E57G8/Screenshot+2019-04-02+at+23.04.44.png Projects - Oscillatory brain markers of network function in adults with Down Syndrome [paper] In this paper we use EEG and Dynamic Causal Modelling to link brain oscillations, cognitive ability, and synaptic function in people living with Down Syndrome. Hamburg et al (2019) Cerebr Cort: 10.1093/cercor/bhz043 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524479812513-HWWDKGL1U7UHEISTOOO3/Capture.PNG Projects - Network dynamics in epileptic encephalopathies [paper] In this paper we illustrate how summary measures of network dynamics can separate subgroups of epilepsies in early infancy. Rosch et al (2017) Net Neurosci: 10.1162/netn_a_00026 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/c6a0d539-5058-4989-94fb-c20ed9f47feb/key_image.png Projects - Spontaneous brain activity emerges from pairwise interactions in the larval zebrafish brain [paper] A maximum entropy model shows simple pairwise interactions are sufficient to explain whole-brain activity. Rosch et al. 2024 Phys Rev X doi.org/10.1103/PhysRevX.14.031050 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/a1960e65-4c40-4709-8a35-3fde10d1d064/Screenshot+2023-04-16+at+13.43.46.png Projects - Microscale neuronal activity collectively drives chaotic and inflexible dynamics at the macroscale in seizures [paper] Single-cell recordings reveal how collective microscale activity produces the rigid, chaotic dynamics of seiuzres. Burrows et al. 2023 J Neurosci doi.org/10.1523/JNEUROSCI.0171-22.2023 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1617456214855-69QT785Z87IUVQTCXJZV/Screenshot+2021-04-03+at+15.12.48.png Projects - Transparent graphene microelectrodes illuminate spatiotemporal seiuzre dynamics at the microscale [paper] Multimodal recordings capture how seizure activity organises across scales in space and time. Driscoll et al. 2020 Comms Biol doi.org/10.1038/s42003-021-01670-9 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1617443066286-A18OC4OE9HI4XZ0YR6PN/Screenshot+2021-04-03+at+11.38.11.png Projects - Imaging epilepsy in larval zebrafish [review] A review of how whole-brain imaging lets us watch seizure dynamics emerge at celluular resolution. Burrows et al. 2020 Eur J Paediatr Neurol doi.org/10.1016/j.ejpn.2020.01.006 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524433030221-K0B1HD0ZMRYEJGT95OG1/Screen+Shot+2018-04-22+at+22.35.30.png Projects - Brain-wide changes in effective connectivity during seizures in zebrafish [paper] Whole-brain imaging combined with dynamic causal modelling traces how seiuzre dynamics emerge across the zebrafish brain. Rosch et al. 2018 PLoS Comp Biol doi.org/10.1371/journal.pcbi.1006375 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/dfcf6778-549b-4527-b916-3fc7257178aa/Screenshot+2026-06-19+at+15.02.29.png Projects - Dynamic causal modelling of seiuzre activity in a rat model [paper] Inferring the circuit changes underlying emergent seiuzre dynamics. Papadopoulou et al. 2016 NeuroImage doi.org/10.1016/j.neuroimage.2016.08.062 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/4fa74166-5ead-4bad-8de8-1b833084d6a3/HBM-46-e70393-g001.jpg Projects - Receptor-density topography shapes intracranial EEG spectra [paper] Usingy dynamic causal modelling, regional differecnes in iEEG activity are explained in part by the local distribution of neurotransmitter recpetors. Stoof et al 2025 Hum Brain Mapp doi.org/10.1002/hbm.70393 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/5515059b-7781-4e88-bb7e-c977dd9a70b7/Screenshot+2026-06-19+at+12.53.03.png Projects - Corticocortical evoked potentials for localising the epileptogenic zone [review] A review of analytical techniques and emerging paradigms that use stimulation-resoponse mapping to probe network architectures. Qiang et al 2025 Epilepsia doi.org/10.1111/epi.18467 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/e0ce2849-251e-4a5b-ae13-4838016b4c71/Screenshot+2026-06-19+at+12.59.05.png Projects - Interictal discharges spread along local recurrent networks between tubers and cortex [paper] DCM reveals the recurrent network structure underlying the local spread of interictal discharges in tuberous sclerosis. Tumpa et al. 2025 J Physiol doi.org/10.1101/691170 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/f8151dc4-458e-43b2-a91f-cbd921491066/Screenshot+2026-06-19+at+13.02.29.png Projects - Modelling cortical networks [paper] How the coupling of neuronal models shapes the dynamics we can observe in them. Cooray et al. 2023 Disc Appl Scie doi.org/10.1007/s42452-024-05624-8 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/f798352a-134f-405a-afed-60c74cd99a2e/journal.pcbi.1010915.g006.PNG Projects - Global dynamics of neural mass models [paper] A formal analysis of how the structure of population models shapes their global dynamical repertoire Cooray et al. 2023 PLoS Comp Biol doi.org/10.1371/journal.pcbi.1010915 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/afb2821b-f948-4496-bb22-2052236ac053/Screenshot+2026-06-19+at+13.11.29.png Projects - Increased modal controllability in drug-resistant focal epilepsy [paper] Structural brain networks in paediatric focal epilepsy show altered controllability of the whole brain and of epileptogenic regions. Chari et al 2021 Comm Biol doi.org/10.1038/s42003-022-03342-8 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/4adb6f70-43f6-4f16-85c3-8c4feebddb8c/Screenshot+2026-06-19+at+14.26.30.png Projects - Hierarchical disruption in the Bayesian brain [paper] Focal epilepsy is associated with disruption of the hierarhical network structure underlying inference. Omidvarnia et al. 2017 NeuroImage Clin doi.org/10.1016/j.nicl.2017.05.019 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/21bd87af-ca14-468d-aa1e-8aed38e773bf/epi70158-fig-0004-m.png Projects - Are seizure forecasts and cycles better than chance? What chance? [paper] A critical look at how seizure cycles and forecasts should be evaluated against the right baseline. Github: Zebrafish seizure modelling https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/29af57aa-0f74-4fc4-a33e-fa0203636519/Screenshot+2024-10-04+at+12.48.10.png Projects - Epileptiform activity and seizure risk follow long-term non-linear attractor dynamics [paper] Long-term recordings reveal that seizure risk drifts along the geometry of a nonlinear attractor. https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/d61d26f6-7476-4a88-b85f-492f66d5affd/Screenshot+2026-06-19+at+15.14.13.png Projects - Rotationally stable dynamics over long timescales emerge in neuronal development [preprint] Developmentally networks support both stability and change mediated through regionally different dynamics. https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/f63b0503-282e-408c-8aed-9e66d7800a1b/Screenshot+2026-06-19+at+15.29.05.png Projects - Chloride dynamics predict optimal strategies for terminating status epilepticus [paper] Modelling how chloride shifts over the course of prolonged seizures points to better-timed treatment strategies. https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/3a65d68d-6422-4098-9716-c2b71684d72e/Screenshot+2023-09-26+at+12.13.10.png Projects - Dynamic changes in synaptic inhibition underlie benzodiazepine resistance in paediatric status epilepticus Synaptic inhibition is dynamically disrupted during prolonged status epilepticus. https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/d8ced55a-aabc-4e08-a0c2-b5edc5906e20/Screenshot+2026-06-19+at+15.22.27.png Projects - Scalp high-frequency oscillation rates depend on sleep stage and decrease with time spent in sleep A clinical biomarker shown to vary systematically with state and time. https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/642297f2-922e-4a42-a1d6-8b60f6b50823/Screenshot+2026-06-19+at+15.30.14.png Projects - Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus A review of how the dynamics of prolonged seizures drive treatment resistance over time http://dynamic-brains.com/about daily 0.75 2026-04-21 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1525186932447-AXWQLJJQWZJ8FAUSD7F2/2016-02-07+09.02.27.jpg About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524434309676-HGRE48E59ZIS1FED7D27/IMG_2864.jpg About - Dynamic Brains Insights into childhood epilepsies as dynamic disorders of the brain https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/7179a89f-2e0e-49b0-83ae-bc821398c59e/profile_books.jpg About - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1603900461050-V9GOQ86IUYDYCVKVZYPM/image.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1627896172160-J7D7936FFLR7I815Y60V/me_2021_formal.jpg About - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/5855f9f1-b5ab-46fa-bb40-c31b110b5f6d/image.jpg About - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1738332789964-UVWIY01HMK0HEW7TCR37/Screenshot+2025-01-31+at+14.13.03.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1681648344524-ZKGYM0J15UEHG6VA2WTL/Screenshot+2023-04-16+at+13.32.04.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1621783485645-T5NA8CLCHG52TI6QQLA7/Logo_AMG-Stifung_CMYK-1.jpg About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1606406027410-IA5HXSZURJNHNNDQMPXA/Screenshot+2020-11-26+at+11.53.19.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1601473539558-GI3905RDO5PH8LU4X64A/human_brain_project.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1595239618393-P2J6MYXSHHGM1KBEEYML/lockup_cloud_main.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1595191705253-Y4FSFFBW0NST1VF8AYKB/wellcome-logo-black.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1595192142189-XAAL0A0OFWY1TOBNCA91/Screenshot+2020-07-19+at+21.55.15.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1595191790513-NFSH83ZQHWX51FH6XVWY/dravet-canada-logo-main.png About https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1776761232430-LFZ8EAO8MITXQWK5KBAZ/unsplash-image-4V1dC_eoCwg.jpg About - Teaching Teaching practical neuroscience through data, code, and real research questions. Information for specific modules below. http://dynamic-brains.com/richard daily 0.75 2025-03-28 https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1525187012408-Y3Q08P4NZIJ30ZGKU7HR/2016-01-15+13.21.27.jpg Richard Rosch https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524482730711-X3ZFTLVRGEWN44XALI6K/2016-02-07+08.56.33.jpg Richard Rosch - Richard Rosch Interests and Bio https://images.squarespace-cdn.com/content/v1/56c4541ff699bb8d36e8a8d7/1524484041755-EU4HHL1CBS48SO2SC341/DOil5jeWsAIA4p9.jpg Richard Rosch - Richard Rosch Curriculum Vitae http://dynamic-brains.com/contact daily 0.75 2024-10-31 http://dynamic-brains.com/calendar daily 0.75 2024-04-18 http://dynamic-brains.com/zoom daily 0.75 2024-04-18 http://dynamic-brains.com/lab daily 0.75 2025-12-29