Emergence of Dynamic Patterns

Some of the brain's most striking behaviours don't live in any single neuron — they emerge from the way large numbers of simple units interact. A seizure, a travelling wave, a moment of brain-wide synchrony: none is written into an individual cell, yet all arise reliably from local interactions between many. Understanding the brain therefore means understanding emergence — how collective patterns appear at one scale that can't be read off from the parts below.

In this research stream we study that jump from microscale activity to macroscale dynamics directly. Across recordings from the zebrafish brain to the human brain under different conditions, we apply statistical-physics approaches such as maximum-entropy models and dynamic causal modelling to ask how local interactions give rise to brain-wide behaviour — and which simple rules are sufficient to reproduce the patterns we observe.

 

Spontaneous brain activity emerges from pairwise interactions in the larval zebrafish brain [paper]

A maximum entropy model shows simple pairwise interactions are sufficient to explain whole-brain activity.

Rosch et al. 2024 Phys Rev X doi.org/10.1103/PhysRevX.14.031050

 

Microscale neuronal activity collectively drives chaotic and inflexible dynamics at the macroscale in seizures [paper]

Single-cell recordings reveal how collective microscale activity produces the rigid, chaotic dynamics of seiuzres.

Burrows et al. 2023 J Neurosci doi.org/10.1523/JNEUROSCI.0171-22.2023

 

Transparent graphene microelectrodes illuminate spatiotemporal seiuzre dynamics at the microscale [paper]

Multimodal recordings capture how seizure activity organises across scales in space and time.

Driscoll et al. 2020 Comms Biol doi.org/10.1038/s42003-021-01670-9

 

Imaging epilepsy in larval zebrafish [review]

A review of how whole-brain imaging lets us watch seizure dynamics emerge at celluular resolution.

Burrows et al. 2020 Eur J Paediatr Neurol doi.org/10.1016/j.ejpn.2020.01.006

 

Brain-wide changes in effective connectivity during seizures in zebrafish [paper]

Whole-brain imaging combined with dynamic causal modelling traces how seiuzre dynamics emerge across the zebrafish brain.

Rosch et al. 2018 PLoS Comp Biol doi.org/10.1371/journal.pcbi.1006375

 

Dynamic causal modelling of seiuzre activity in a rat model [paper]

Inferring the circuit changes underlying emergent seiuzre dynamics.

Papadopoulou et al. 2016 NeuroImage doi.org/10.1016/j.neuroimage.2016.08.062