Understanding Whole Brain Dynamics
In the end, what reaches the clinic is the behaviour of the whole brain. Making sense of whole-brain, observable phenomena means working at the scale where everything integrates. This is where the molecular, structural, emergent, and temporal threads of our work come together, and where they may relate back to the clinic.
In this research stream we read the network-level signatures of brain activity in patients. We analyse scalp and intracranial recordings to characterise how whole-brain dynamics differ in health and disease by measuring network organisation, complexity, and oscillatory structure. Turning whole-brain dynamics into quantities, we work toward tools that support real clinical decisions.
Oscillatory brain markers of network function in adults with Down Syndrome [paper]
In this paper we use EEG and Dynamic Causal Modelling to link brain oscillations, cognitive ability, and synaptic function in people living with Down Syndrome.
In this paper we illustrate how summary measures of network dynamics can separate subgroups of epilepsies in early infancy.
Rosch et al (2017) Net Neurosci: 10.1162/netn_a_00026