Temporal Evolution of Brain Dynamics
Brain dynamics are never still. The same network behaves differently from one moment to the next, over the course of a seizure, across a night's sleep, through development, and across cycles that play out over days or weeks. Much of what matters clinically lives in this change over time: whether a seizure will stop, when the next one is likely to come, how a developing brain settles into stable patterns. A snapshot rarely tells the whole story.
In this research stream we treat time as the central variable. We model how dynamics evolve — from the fast collapse of a seizure into benzodiazepine resistance, to the slow drift of seizure risk over months — using tools from nonlinear dynamics, including attractor models and the study of long-term cycles. By tracking how patterns build, persist, and break down, we ask not just what the brain is doing, but where its dynamics are heading — and how reliably that can be anticipated.
Are seizure forecasts and cycles better than chance? What chance? [paper]
A critical look at how seizure cycles and forecasts should be evaluated against the right baseline.
Github: Zebrafish seizure modelling
Epileptiform activity and seizure risk follow long-term non-linear attractor dynamics [paper]
Long-term recordings reveal that seizure risk drifts along the geometry of a nonlinear attractor.
Rotationally stable dynamics over long timescales emerge in neuronal development [preprint]
Developmentally networks support both stability and change mediated through regionally different dynamics.
Chloride dynamics predict optimal strategies for terminating status epilepticus [paper]
Modelling how chloride shifts over the course of prolonged seizures points to better-timed treatment strategies.
Dynamic changes in synaptic inhibition underlie benzodiazepine resistance in paediatric status epilepticus
Synaptic inhibition is dynamically disrupted during prolonged status epilepticus.
Scalp high-frequency oscillation rates depend on sleep stage and decrease with time spent in sleep
A clinical biomarker shown to vary systematically with state and time.
Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus
A review of how the dynamics of prolonged seizures drive treatment resistance over time